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Epigenomics: Expanding Insight into Human Health and Potential Future Implications

on August 29, 2023

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The Effective Use of AI Models in Early Detection of Genetic Disorders and Diseases

on August 29, 2023

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Anirudh: Welcome to my page. Here you would find a variety of topics. You would find research articles and comparisons in the same for a layman explanation for people with no background in science to enjoy reading and understand. I would occasionally also post topics on mental and personal wellbeing. Hoping to hear from you on any suggestions and arguments you would have.

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A Student’s Guide to Sweden: Don’t Panic and Bring a Warm Coat

New Country, New Language, New Education – The Unspoken of Moving to a New Country *** "Observe how long we remember our victories and how soon we forget our defeats memory is the menial of will" -Essays, "Counsels and Maxims," p.126 *** Moving to a new country is like stepping into a kaleidoscope: vibrant, unpredictable, and sometimes overwhelming. The last time I left India, I was closer to my 20s than this time around, the pandemic hadn't yet struck, and people were still careless with their hugs and handshakes but more importantly, the last time I left India, I had an excitement that exceeded my own desires for self but this time when I left for Sweden, I knew I was embarking on an adventure that would shape my life in unimaginable ways. But no amount of research or preparation could truly prepare me for the challenges (and rewards) - of a new country and of navigating a new environment, language, and culture. I've traveled and lived in many cities and ...

A Fischer Mendel controversy

Ronald A. Fisher, one of the most influential statisticians of the 20th century, is widely recognized for his contributions to the field of statistics and population genetics. Born in 1890, Fisher's work on statistical methods and evolutionary theory shaped the modern understanding of genetics. In the 1930s, he became known for critiquing Gregor Mendel's famous experiments on pea plants, suggesting that Mendel's results were “too perfect” to be entirely natural. Gregor Mendel, a 19th-century Augustinian monk, published his groundbreaking work on heredity in 1866. His experiments with pea plants laid the foundation for the laws of inheritance. However, his work went largely unnoticed until its rediscovery around 1900 by three independent scientists—Hugo de Vries, Carl Correns, and Erich von Tschermak. Mendel's research explained the inheritance of traits through dominant and recessive alleles, which are now central to modern genetics. Fisher’s statistical analysis of Men...

An escape to reality

I am contemplating writing this blog as i do write it but after days and weeks of contemplation i think i have found purpose for this wee blog. I would be turning 25 this year and life seems to be at a standstill with work stagnating and my personal life and relations being strained to new extremes. Maybe in a strange way, i am hoping this article of my little escape to find closure and comfort with familiar faces in unfamiliar places would act as a guide or better yet reassure someone facing the same predicament. To put a date on where this began, it would be rather difficult but a place i can begin would be from February 14th. I had just arrived back in India, heartbroken from being failed by my employers at tending to and acknowledging the efforts put in by their employees. I had pondered over the conditions for weeks and finally, i am now home. I was exhausted and i needed change but comfort. That is where this begins, on February 14th, when ...

Investigating the effects of Mitochondrial DNA Copy Number deregulation in tumourigenic cells

For the Data tables, Images and Projections, please contact the author directly for the Appendix- sections 1 & 2 Abstract : Evidence of quantitative variations in overall mitochondrial DNA (mtDNA) copy numbers have been observed across various tumours. Their variations are not aligned to a common increase or decrease across all tumours, instead they are found differing in different tumours. To further understand these variations, multiple strategies attempted have been discussed in this paper to provide insights into the commonalities in the interplay between mitochondrial genes and the associated nuclear genes in tumours observed with low mtDNA copy number and tumours observed with high mtDNA copy numbers. A literature review of existing data was conducted which forms the basis of the experiments executed and the results acquired. A case control of over 37 tumour types comprising in total of 2,180 samples have been included in the study in addition to the online databa...

Epigenomics: Expanding Insight into Human Health and Potential Future Implications

Epigenomics is a field of study that investigates modifications to DNA and its associated proteins that regulate gene expression, without altering the underlying genetic code. It provides vital insights into the mechanisms by which environmental factors and lifestyle choices can influence gene activity. Epigenomic research holds immense promise for understanding the development of diseases, improving diagnostics, and potentially shaping the future of the human race. In this essay, we will delve into the uses of epigenomics and explore its potential future applications in advancing human health and well-being. Understanding Epigenomics: Epigenomics is the study of epigenetic modifications, which include DNA methylation, histone modifications, and non-coding RNA. These modifications play a crucial role in gene regulation and can determine whether a gene is turned on or off, or the extent to which it is expressed [1] . By mapping and analyzing these epigenetic marks along the genome, rese...

The Effective Use of AI Models in Early Detection of Genetic Disorders and Diseases

Introduction: The field of genetics and genomics has made remarkable progress over the years, offering unprecedented insights into human health and disease. However, the sheer complexity of analyzing vast amounts of genomic data poses a significant challenge in the early detection of genetic disorders and diseases. With the advent of Artificial Intelligence (AI) and machine learning, there is now a promising avenue for leveraging AI models in the early detection of genetic disorders and diseases. In this blog post, we will explore the effective use of AI models in early detection, its benefits, challenges, and future prospects. Understanding AI Models: AI models are designed to emulate human intelligence, enabling computers to perform complex tasks such as pattern recognition and data analysis. Machine learning, a subset of AI, allows computers to learn and improve from experience without being explicitly programmed. By feeding AI models with large datasets, they can identify patterns ...

Education, Assessments and Research spirit of India

E.A.Rs of India Introduction: India, a global hub for IT, tech support and tourism is now finding its way into becoming self sufficient and a leader in manufacturing practises. With the population set to exceed that of China's, it would be redundant of me to speak any further without pointing out the importance of manpower in the requirement of a country to becoming one of the strongest in the world as a hub for development, if led politically and diplomatically well. That being said, India is yet to realise her potential herself, contained by her own policies that predate the 70s with regard to education reform, with a wide variety of political involvement in what should be taught and what should be left to forget, salaries and infrastructure that refrain from motivating even the most underprivileged in rural societies. How then can a country and its citizens grow, if members of the educational and research wing be regarded lesser than caretakers of society; where teachers, resear...

The Transformative Role of Wet Lab Work in Scientific Research: A Journey of Self-Improvement and Psychological Development

Scientific research, particularly in the life sciences, often necessitates extensive laboratory work, commonly referred to as "wet lab work." This essay delves into the profound influence of wet lab work on the self-improvement and psychological development of scientific researchers. It explores how the challenges, setbacks, and successes experienced in the laboratory contribute to personal growth, fostering qualities such as resilience, patience, and adaptability. Furthermore, this essay examines the interplay between scientific research, wet lab work, and mental health, emphasizing the importance of a balanced approach to self-improvement in the demanding world of scientific inquiry. Scientific research is a journey of discovery, exploration, and innovation. It is an endeavor characterized by curiosity, determination, and the pursuit of knowledge. Within the realm of scientific research, wet lab work occupies a central role, offering researchers hands-on experiences and opp...

Starting Strong: A Roadmap to Success in Your Career

I recently started working for a company based out in India. I was well aware of the working conditions and general nature of peers and employers here because of my past experiences of having studied and worked in India. However, i could not have been more prepared of what would come ahead. The science industry is in itself grueling and rather a grind for most recent graduates and newbies in the professional sphere of working. I remember my mentor and many others talking about a need for an inclusive environment that thrives on a leadership by inspiration model, as opposed to the whip and fear tactic of functioning. In my first month alone, I understood the true meaning and what differentiates college politics from office politics, let alone the way the mind morphs when subjected to a significant period of time in a repetitive and monotonous working environment. I feared for my minds ability to move dynamically at grasping and conversing with people on differe...

Procrastination: Deconstructed

Everyone at some stage or another faces procrastination. I for one have it creeping in on me every Tuesday. As ridiculous as that sounds, its common to find yourself procrastinating and putting off meetings, tasks and initiatives. One thing for certain is it can be induced by circumstances, emotional condition, environment or purely exhaustion. When one lives day in and day out, one may find themselves constructing a plan or thought that they feel they must commit to and accomplish however it is not those showers or 2am thoughts that accomplish them but the will you generate to make the first steps towards your tasks. Here I would like to provide my insights on how one could self-assess, acknowledge and move forward past the desire to not do as they wished for. The best way to define procrastination would be to term it as a phase of failure to self-regulate brought on by irrational delays despite the risks of potentially negative consequences. So let us work backwards here. You...

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